Combination therapies augment the anti-tumor activity of agonist CD27 mAb in human CD27 transgenic mouse models
نویسندگان
چکیده
منابع مشابه
Combination therapies augment the anti-tumor activity of agonist CD27 mAb in human CD27 transgenic mouse models
CDX-1127 is a fully human antibody to CD27, a TNF receptor superfamily member expressed on the majority of T cells and subsets of NK cells and B cells. We have previously characterized the co-stimulatory activities of CDX-1127 with human T cell cultures and a human CD27 transgenic mouse model (hCD27-Tg). Similar to the findings originally shown by M.J. Glennie and colleagues using an agonist an...
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ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2013
ISSN: 2051-1426
DOI: 10.1186/2051-1426-1-s1-p76